Project C1: Tailored approaches to generate beta cells from human pluripotent stem cells
Diabetes represents one of the most spread diseases worldwide. The in vitro generation of insulin-producing pancreatic beta cells from stem cells helps to better understand its pathophysiology and improves cell therapy strategies.
Project C5: Role of secreted factors for white and brown adipocyte differentiation
Brown adipose tissue (BAT) is the key thermogenic tissue in rodents and newborns, but is also present and active in human adults. It is involved in body weight regulation and thus discussed as a therapeutic tool to combat obesity in humans.
Project C6: Characterization of mechanisms involved in regeneration and re-differentiation processes of beta-cells in diabetes
Current hypotheses claim de-differentiation of beta-cells as part of the human diabetes pathology. We use reversible mouse diabetes models to define underlying mechanisms responsible for regeneration/re-differentiation of beta-cells.
Project C9: XenFish, a rapid screening platform to study intracellular signal transduction and cellular differentiation
Application of the XenFish screening platform for the identification of proteins with regenerative potential in type 2 diabetes