Project P1: P2X receptors in the lung epithelium: function and role in the pathogenesis of transport and secretory disorders
We have recently described that P2X4 receptors facilitate release of pulmonary surfactant and alveolar fluid transport in primary alveolar epithelial cells.
Project P3: Damage and regeneration of lung epithelial barrier during inflammatory lung diseases
Breakdown of epithelial barrier function is a hallmark in chronic inflammatory lung diseases such like COPD and asthma. Inflammatory factors not only regulate immune response but also interfere with lung epithelial barrier function.
Project P9: Virus-induced impairment of lung epithelia
Viral infection of the lung can lead to a severe impairment of its respiratory function either directly by virus replication related damage of lung epithelia or indirectly by inflammatory responses.