Project C5: Role of secreted factors for white and brown adipocyte differentiation

In the current funding period, we concentrate on preadipocytes-secreted factors and their impact on brown adipocyte differentiation using our state-of-the-art model of ex vivo differentiated primary human deep neck preadipocytes. Secreted factors and their respective receptors are promising targets to develop novel drugs for obesity treatment by promoting brown adipocyte differentiation. We hypothesize that the progenitor pool within the adipose tissue releases factors, which modulate either white or brown adipocyte differentiation in an auto-/paracrine manner.

 

Fig.: UCP1 (UCP1/DAPI) immunostaining of differentiated adipocytes from brown adipocyte progenitor cells ex vivo.