- Project I1: Funktion der Histon H2A Deubiquitinase 2A-DUB/Mysm1 in T Zell-Differenzierung und Autoimmunität
Project I2: Influence of inflammation on the differentiation and function of MDSCs and T cell-mediated immune responses
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells inhibiting T cell expansion and functions and can be applied as cellular therapy for T-cell-mediated diseases.
Project I3: Induction and manipulation of therapeutic immune responses in murine pancreatic cancer as platform to establish novel strategies to target PDAC (ITIP)
The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) in man is caused by potent cellular and paracrine immunosuppressive mechanisms that restrain CD8+ T cell-mediated anti tumour immunity.