Project I2: Influence of inflammation on the differentiation and function of MDSCs and T cell-mediated immune responses

This project aims to clarify how the disease-specific inflammatory environment influences the outcome of a MDSC therapy.  By using three different murine disease models (graft-versus-host disease (GVHD), adipositas and trauma) the differentiation and immunosuppressive capacity of MDSCs and their subsequent effect on the adaptive immune response will be determined. This work will help to estimate the therapeutic success of MDSC treatment dependent on the disease entity.

Fig.: In bone-marrow transplanted mice (BM) the co-transplantation of in vitro-generated MDSCs prevents GVHD-induced death (A) by changing the T cell response towards a type 2 response characterized by the expression of IL-5 in the serum (B).